Science Press Wang Fengpeng
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Since 1806, the German scholar Satuna from opium into morphine base, development of natural product chemistry has been more than 200 years.The research about the 1.5 century almost focuses on the isolation, purification and structure elucidation by chemical method.Undoubtedly, in twentieth Century 40 ~ 80 years is an important period of development of natural product chemistry.In the past 20 years, along with the revolutionary development of separation method and modern spectrum technology, research on natural products chemistry has made considerable progress.At present, isolation and structure of natural products have been routine, popularization.However, new research fields such as molecular biology and genomics of the emergence and development of the research content of natural product chemistry has been enriched and extended.Natural products chemistry is in a new period of development.So, whether to continue in the discovery and new drugs and biological inducers of chemical, biological research, or in revealing the essence of life, natural product chemistry will play an increasingly important role.Research on natural products chemistry in China began in the nineteen twenties, after several generations of decades of human effort, significant progress has been made.Study on isolation and structure of the overall level and foreign similar.However, the level of the synthesis of natural products still lags behind that of developed countries, and the new technologies and new methods, and new research field is still in the "catch" state.Considering the present situation and development trend of natural product chemistry, modern natural product chemistry by Professor Wang Fengpeng editor of the guiding ideology on history of the development of a more comprehensive summary of natural product chemistry, current situation and development trend, study on biosynthesis, stereochemistry, structure and distribution of the classification, source, chemical properties and reactions and combinatorial biosynthesis.The book collects a lot of important references, students for the class, guide book, using inductive brushwork, systematically sums up the theory and knowledge of natural product chemistry.This is a successful and rich in characteristics.Similar books so far less. the book from the beginning to the final finished writing, after 10 years, during which a few easy outline and draft, revising, quite to force.This fully reflects the book edited by some thoughts on the development of chemistry of natural products.The structure is rigorous, logical, concise language, to achieve the desired both "forest" and "tree" purposes.In addition, editors have rich experience for many years engaged in natural product chemistry teaching and research.So, I believe the book to have the basic theory and knowledge of natural product chemistry teaching and scientific research workers as well as the research of natural organic chemistry, medicinal chemistry of natural and synthetic drugs chemical professional students is a very worth recommending reference book.
The book by the general and all of two parts.General section includes introduction, biosynthesis and stereochemistry, focuses on the influence of generation and development of natural product chemistry of natural drug discovery and research status and development trend, principle and pathway of biosynthesis and stereochemistry.The theory summarizes the main types of natural products, generally includes a summary, biosynthesis, structure classification / student relationship and distribution, stereochemistry, chemical properties and reactions.Part of the chapter focuses on examples described the total synthesis of the dose-effect relationship and the chemical and structural modification.With the development of recombinant DNA technology and the identification of genes and its application to combinatorial biosynthesis, matching technology, combinatorial biosynthesis will become one of the most important source of new structure and new type compounds.In view of this, the last chapter on combinatorial biosynthesis of natural products, the basic concepts, strategies, and commonly used technology in polyketide natural products such as applications, summarized the discussion. book for natural organic chemistry, pharmaceutical chemistry, Chinese herbal medicine chemistry, plant chemistry, organic chemistry research, teaching reference, but also as a graduate textbook use.
The first order general the first chapter of the first day of natural product chemistry, the emergence and development of , a national medicines and natural product chemistry germination period two, organic chemistry and natural product chemistry early, mid-term development and modern methods of establishment and development of three, structure and biosynthesis of natural products historical review of four, synthesis of natural products research is briefly outlined in section second of natural product chemistry and natural drug , natural product chemistry of Natural Medicine found that the influence of two, China's natural medicine research overview in section third of natural product chemistry research status and development trend of , the present research situation of two, the development trend of reference chapter second natural organic product classification first chemistry structure classification method in section second of physiological activity classification third source classification fourth source classification fifth students combined with chemical classification references third chapter of natural product biosynthesis of in section one, basic concepts of two, three, a brief history of the development of natural product biosyntheticThe main "component" second section of natural product biosynthesis principle in section third of natural product biosynthesis pathway, acetate-malonate pathway of two, three, shikimate pathway prenylation pathways of four, five, compound amino acid pathway pathway of reference fourth chapter stereochemistry of first section the basic concept of , classification of two, three, and the stereochemistry of chiral molecular symmetry four, ectopic and chiral second configuration and conformation of the said , configuration, conformation of two third conformation and conformational analysis of , two, various compounds three, conformation conformation analysis of the basic principle of four, conformational analysis application in section fourth of group and gauche effects , two, gauche effect of the end group effect of < br> reference second fatty acids, saccharides and glycosides, amino acids and peptides fifth fatty acids and fatty acid section grease second section twenty eicosapentaenoic acid order type metabolites , prostaglandin , thromboxane two class three, class four, ω - leukotriene third fatty acids and fatty acid related compounds , acetylenic compounds two, allyl compounds reference chapter sixth sugar and glycoside first sugar , two, three, the stereochemistry of monosaccharide sugars chemical properties and reaction of four, sugar synthesis and application in the synthesis of natural products by second, two, classification and nomenclature of glycosidic bond cleavage of three, glycoside bond formation of reference chapter seventh amino acid and peptide amino acids , two, stereo chemical classification second plant cyclopeptides , classification and distribution two, three, four properties, synthesis of natural bioactive polypeptide reference third carbon ring aromatic compounds eighth chapter phenylpropanoid section section second benzene propylene , biosynthesis of two, three, classification and distribution of the biological activity of third α - Pyrones a, classification, biogenetic relationship and distribution of two, structural modification and structure-activity relationship of three, biological activities and medicinal value of fourth lignans and Neolignans , students
Section fourth of br> classification, biogenetic relationship and distribution of , acyclic monoterpene two, three monoterpenoids, bicyclic monoterpene Fifth Festival named , acyclic monoterpene two, two methyl cyclohexane monoterpenoid three, P four, cover alkyl monoterpene cyclic enol ethers terpane five, six, monoterpene phenols chrysanthemum alkyl monoterpene seven, eight menthane monoterpenes, carane monoterpene nine, pinane monoterpene ...... twelfth chapter sesquiterpene thirteenth chapter two terpene fourteenth chapter three terpene and terpene fifteenth chapter dolichol - carotenoid sixteenth chapter steroid fifth natural organic compounds containing nitrogen seventeenth chapter alkaloid chapter eighteenth non combinatorial biosynthesis nineteenth chapter composition alkaloid nitrogenous compounds sixth natural products the synthesis principle and application Chinese abbreviations of index index
The first chapter thread diagnosis natural product chemistry is a subject based on organic chemistry, analytical chemistry and biosynthesis as the foundation, comprehensive discipline at the same time, including biology, medicine and pharmacology part. natural product chemistry germination in the establishment and development of national medicine, and produced in organic chemistry and modern methodology.Generally, natural product chemistry began in 1806, the German scholar F.wSertfimer from opium into morphine base.However, if we consider the Swedish chemist Scheler in 1769 ~ 1785, segregation of organic acids, such as tartaric acid, citric acid, malic acid, lactic acid, uric acid, gallic acid and oxalic acid, also should be more earlier.The synthetic chemistry began in 1828 Wu Le synthesis of urea.Before the nineteen forties, separation, purification and chemical structure elucidation of natural products research is almost focused on organic products.40 to 80 years, is an important development period of natural product chemistry.With the continuous development of the chromatographic method and modern spectrum technology, structure elucidation work gradually replaced by spectrometry.Study on the speed and quality of ingredients of natural products chemistry has been hitherto unknown development.Although the chemical synthesis of the natural product is no longer the only source of medication, but natural products is still one of the most important approaches to drug discovery.Since the 70's, along with chromatography technology, biotechnology, chiral technology and information technology, many new technologies continue to emerge, especially molecular biology, molecular pharmacology, molecular pathology, microelectronic technology and genomics, proteomics, glycomics emergence and development, the new climax of natural product chemistry also, the natural product chemistry classic in a "new era of thoroughly to remould oneself". currently, object of natural product chemistry is mainly natural products from plant, animal, fungi, bacteria, microorganisms and marine organisms.Research involves many disciplines, including the humanities, plant / chemical classification, chemistry, molecular biology and enzymology, genetic engineering and marine and terrestrial ecology, information science etc..The main contents of the study include the extraction effect and its mechanism and a new resource isolation, structure determination, semi-synthetic, total synthesis, biological active components and the development of biosynthesis and genetic engineering.Research task and objective natural product chemistry is based on its chemical composition and its forming process and Study on biological activity in vivo, drugs to invention, discovery, make useful compounds or biologically active components.In the process that the phenomena of life, natural product chemistry in the future will play an irreplaceable role.At the same time, people will face a series of challenges.To make a long story short, in the study of natural product chemistry, whether to continue in chemistry, biology and the discovery of new drugs and biological inducers, and reveal the nature of life such as identification of neurochemical, hormone, visual chemical substances, will become more and more important. due to limited space, this chapter only produce and development, natural product chemistry of natural product chemistry and natural medicine and natural product chemistry research status and development trend.To summarize the discussion.
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